2025

Comprehensive atomic-scale 3D viral-host protein interactomes enable dissection of key mechanisms and evolutionary processes underlying viral pathogenesis
Li L*, Roy PG*, Liu Y, Zhang Z, Savan R, Gokhale NS, Schang LM†, Das J†, Yu H†.
bioRxiv. (2025) (†Co-corresponding authors, *Equal contribution). Under review.

CELF2 suppresses endogenous-RNA ligands that activate RIG-I-mediated interferon induction
Smith JR*, Kern OC*, Mishra G, Gokhale NS, Etzyon N, Somfleth K, Schwerk J, Nakamichi K, Pugliano C, Lindbloom-Brown Z, Gale M, Savan R.
bioRxiv. (2025) (*Equal contribution). Under review.

Interleukin-2 mediated NF-kB-dependent mRNA splicing modulates interferon gamma protein production
Van Gelder RD, Gokhale NS, Genoyer E, Omelia DS, Anderson SK, Young HA, Savan R.
EMBO Reports. (2025) 26(1):16-35. Epub ahead of print 2024. PMID: 39578552.

2024

Cellular RNA interacts with MAVS to promote antiviral signaling
Gokhale NS†, Sam RK, Somfleth K, Thompson MG, Marciniak DM, Smith JR, Genoyer E, Eggenberger J, Chu LH, Park M, Dvorkin S, Oberst A, Horner SM, Ong S-E, Gale M, Savan R†.
Science. (2024) 386(6728):eadl0429. PMID: 37808873. (†Co-Corresponding authors).
- Highlighted in Science - Best S and Hage A. (2024) Platform influencers—host RNA control of antiviral immunity. PMID: 39700296.
- Highlighted in Trends in Immunology - Liu Y and Cao X. (2025) Cellular RNA acts as an antiviral MAVS signalosome scaffold. PMID: 39890549.

2023

Structure-first identification of conserved RNA elements that regulate dengue virus genome architecture and replication
Boerneke MA, Gokhale NS, Horner SM, Weeks KM.
PNAS. (2023) 120(15):e2217053120. PMID: 37011200.

2022

ADAR1 mutation causes ZBP1-dependent immunopathology
Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A.
Nature. (2022) 607:769-775. PMID: 35859177.

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Castro LK, Beierschmitt CM, Turcotte EA, Fay EJ, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD.
PLoS Biology. (2022) 21(6): e3002144. PMID: 37289745. 

2021

RNA regulatory mechanisms that control antiviral innate immunity
Gokhale NS, Smith JRS, Van Gelder R, Savan R.
Immunological Reviews. (2021) 304:77-96. PMID: 34405416. (Review).

Endomembrane targeting of human OAS1 p46 augments antiviral activity 
Soveg FW*, Schwerk J*, Gokhale NS, Cerosalatti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang T-Y, Ozarkar S, Clingan JM, McAnarney ET, Stone AEL, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M, Savan R.
eLife. (2021) 10:e71047. PMID: 34342578. (*Equal contribution).

FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression
McFadden MJ*, Sacco MT*, Murphy K, Park M, Gokhale NS, Somfleth KY, Horner SM.
Journal of Molecular Biology. (2021) 434(6): 167247. PMID: 34537236. (*Equal contribution).

The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis 
Bechara R, Amatya N, Bailey RD, Li Y, Aggor FEY, Li DD, Jawale CV, Coleman BM, Dai N, Gokhale NS, Taylor TC, Horner SM, Poholek AC, Bansal A, Biswas PS, Gaffen SL.
Science Immunology. (2021) 6(61): eabd1287. PMID: 34215679.

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
McFadden MJ, McIntyre ABR, Mourelatos M, Abell NS, Gokhale NS, Ipas H, Xhemalce B, Mason CE, Horner SM.
Cell Reports. (2021) 34(9):108798. PMID: 33657363.

2020

Altered m⁶A modification of specific cellular transcripts affects Flaviviridae infection
Gokhale NS*, McIntyre ABR*, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM.
Molecular Cell. 77(3):542-555. PMID: 31810760. Cover article. (*Equal contribution).
- Highlighted in Nature Reviews Molecular Cell Biology - Barranco C. (2020) Viral infection linked to m6A alterations in host mRNAs (PMID: 31853005).

Limits in the detection of m⁶A changes using MeRIP/m6A-seq
McIntyre ABR, Gokhale NS, Cerchietti L, Jaffrey SR, Horner SM, Mason CE.
Scientific Reports. (2020) 10(1):6590. PMID: 32313079.

The mRNA cap 2’O methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes
Williams GD, Gokhale NS, Snider D, Horner SM.
mSphere. (2020) 5(3):e00202-20. PMID: 32404510.

Direct RNA sequencing reveals m⁶A modifications on adenovirus RNA are necessary for efficient splicing
Price AM, Hayer KE, McIntyre ABR, Gokhale NS, Szeto J, Della Ferra AN, Mason CE, Horner SM, Wilson AC, Depledge DP, Weitzman MD.
Nature Communications. (2020) 11(1):1-17. PMID: 33243990.

Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
da Silveira WA*, Fazelinia H*, Rosenthal SB*, Laiakis EC*, Kim MS*, Meydan C*, Kidane Y*, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian S, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Leo Elworth RA, Sapoval N, Treangen T, Schisler JT, Gokhale NS, Horner SM, Singh LN, Wallace D, Willey JS, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A.
Cell. (2020) 183(5):1185-1201.e20. PMID: 33242417. Cover article. (*Equal contribution).

2019

Regulation of viral infection by the RNA modification N6-methyladenosine
Williams GD, Gokhale NS, Horner SM.
Annual Review of Virology. (2019) 6(1):235-253. PMID: 31283446. (Review).

2018

Pervasive tertiary structures in the dengue virus RNA genome
Dethoff EA*, Boerneke MA*, Gokhale NS, Muhire BM, Martin DP, Sacco MT, McFadden MJ, Weinstein JB, Messer WB, Horner SM, Weeks KM.
PNAS. (2018) 115(45):11513-11518. PMID: 30341219. (*Equal contribution).

N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle
Imam H*, Khan M*, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, Kim SJ, Mason CE, Horner SM, Siddiqui A.
PNAS. (2018) 115(35):8829-8834. PMID: 30104368. (*Equal contribution).

2017

RNA modifications go viral
Gokhale NS, Horner SM.
PLoS Pathogens. (2017) 13(3):e1006188. PMID: 28278189. (Review).

Knotty Zika virus blocks exonuclease to produce subgenomic flaviviral RNAs
Gokhale NS, Horner SM.
Cell Host and Microbe. (2017) 21(1):1-2. PMID: 28081439. (Preview).

Protect this house: cytosolic sensing of viruses
McFadden MJ, Gokhale NS, Horner SM.
Current Opinion in Virology. (2017) 22:36-43. PMID: 27951430. (Review).

2016

N6-methyladenosine in Flaviviridae viral RNA genomes regulates infection
Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willier J,Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM.
Cell Host and Microbe. (2016) 20(5):654-665. PMID: 27773535. Cover article.

Post-transcriptional m⁶A editing of HIV-1 mRNAs enhances viral gene expression
Kennedy EM, Bogerd HP, Kornepati AVR, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, Cullen BR.
Cell Host and Microbe. (2016) 19(5):675-685. PMID: 27117054.

2014

Hepatitis C virus: strategies to evade antiviral responses
Gokhale NS, Vazquez C, Horner SM.
Future Virology. (2014) 9(12):1061-1075. PMID: 25983854. (Review).

Characterization of lung inflammation and its impact on macrophage function in aging
Canan CH*, Gokhale NS*, Carruthers B, Lafuse WP, Schlesinger LS, Torrelles JB, Turner J.
Journal of Leukocyte Biology. (2014) 96:473-80. PMID: 24935957. (*Equal contribution).